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Sunday, November 24, 2024

Scientific Integrity and COVID-19 | Nanotechnology Weblog


I’ve written about validating scientific findings beforehand.  With the present COVID-19 (coronavirus) scenario, there have been quite a few revealed claims of varied “information”, that are primarily based on fashions.  It was solely a few months in the past that the information carried projections of 8 billion folks being contaminated and 80 million folks dying.  That later quantity was lowered to 40 million.  Within the US, there have been projections of as much as 3 million folks in the USA dying, which quantity has been repeatedly lowered to probably a most of 200,000, however with a chance of the quantity being a lot decrease.  The present variety of reported deaths is simply over 60,000 as I write this weblog.

The “information” two months in the past had been 80 million worldwide would
die, and now that quantity is presently at 226,882 world-wide who’ve died (up to date
April 30, 2020) with a projected whole to be within the mid to higher 100,000s.  This present pattern signifies that the whole
quantity might be lower than 1% of the unique projection!  What occurred?  There are numerous questions that should be
answered, however that must be completed by the builders of the mannequin. 

The problem that might be addressed beneath is why fashions and the
subsequent outcomes should be understood with the intention to appropriately clarify what the
“information” offered really imply.

First, the data offered as “information” weren’t “information”
however projections primarily based on somebody’s mannequin of the scenario.  A remark years in the past by a good friend, Professor
Bob Shannon of Texas A&M defined it effectively. 
“All fashions are WRONG, some are helpful!”   A robust assertion, which we’ll discover.  

Why are all fashions incorrect? 
The reply is that fashions are primarily based on assumption.  (I’ve spent appreciable time working in
modeling.) The mannequin is barely as right because the mathematical description of the
object being evaluated, the accuracy of the assumptions being made, the
inclusion of all the important thing variables, and an estimate of the in all probability of the variables
occurring.  Often fashions are constructed,
examined, modified, examined once more, and at last run a number of instances over a set of
chances.  The resultant solutions
yield a potential projection with a likelihood vary.  There are often outcomes that present the
extremes in addition to essentially the most possible. 
Due to this fact, the ANSWER will not be a single quantity however a variable with a
likelihood vary primarily based on sure assumptions. 
Discover the phrase “assumptions”, it’s plural.  The outcomes of the mannequin are solely pretty much as good as
the assumptions.  In the event you have no idea the
assumptions, you might be unable to judge the outcomes from the mannequin.  As well as, fashions should be improved as
the evaluation continues.  This is the reason it
known as modeling.  There are some
recommendations that the fundamental virus affect mannequin has not modified. [Ref. #1]  That in itself is uncommon.  Fashions should be regularly up to date to mirror
studying from earlier variations.

A commentary by Holman W. Jenkins, Jr. [Ref. #2] supplies
ideas in regards to the media not with the ability to perceive multivariate.  That is the truth that issues aren’t easy
“if A, then B”.  A brief model of this
is: “When it rains, Jack all the time wears a hat”. 
Does this indicate that Jack carrying a hat causes it to rain?  In fact not.  However there are different variables.  Does Jack have to maintain his head coated due
to a pores and skin drawback?  Does Jack all the time put on
a hat rain or shine?  That is easy
instance.  However, when reporting reduces a
story to a single quantity, it loses the contributing elements.  A greater understanding of how fashions work is
required to have the ability to precisely report on it.

Sure, there’s a want to judge conditions that will trigger a
singularity – additionally referred to as a black swan occasion. 
At one-time, black swans had been thought of fiction, then folks discovered
one.  It was uncommon on the time.  Now they don’t seem to be that uncommon.  Lately, the 100-foot rogue waves had been first
thought of fiction after which black swan occasions. 
Due to satellite tv for pc imaging, we now know that they occur comparatively
usually is for certain a part of the world with sure situations.  The purpose being that wanting on the outcomes
of a mannequin, one wants to contemplate the opportunity of such occasion, however not use
that as the ultimate reply.  Is it potential
that 8 billion of the present 8.8 billion folks may get the virus?  A 91% world an infection fee?  Presumably sure, however that will not be essentially the most
possible and require a big reevaluation of the modeling assumptions. 

What we, as the general public, want to listen to and perceive is what
the assumptions had been in creating the fashions. 
The primary mannequin is what’s the whole affect and the way is it unfold over
time.  The second mannequin is what’s being
proposed and what’s that affect.  The
concern on the present scenario that required governmental interplay was the
potential for an enormous variety of circumstances that will overwhelm the medical
system.  Through the use of a distancing mannequin of 6
ft and a requirement of sheltering in place, the speed of an infection is slowed
and happens over an extended interval so the medial services wouldn’t be
overwhelmed.  It’s not indicating that
the fatality fee is decrease as a result of these laws.  It has solely been delayed.  If a vaccine is created, it can decrease the
fatality fee.  To be presenting something
in any other case is a sign of not understanding what the fashions are
saying.  Giant quantity projections could get
folks nervous and supply income for media, however the massive quantity projections
find yourself forcing the improper allocation of assets.      

The Mayo Clinic responded to the projections that the COVID-19 would require main useful resource allocation.  This resulted within the cessation/postponement of elective surgical procedures, most cancers therapies, and different associated medical procedures.  This huge projected variety of severe unwell folks didn’t occur.  The end result was the Mayo Clinic is furloughing and/or giving pay cuts to about 1/3 of its 70,000 staff. [Ref. #3] This doesn’t embody the affect on associated, externally contracted employees.  And, that doesn’t even tackle the affect on the sufferers who had been unable to have their procedures. 

Might all of this over allocation of assets be primarily based on the lack of know-how of understanding what’s concerned is establishing steerage primarily based on unknowns in fashions?  One must know what’s concerned within the assumptions, variables, and chances.  After the fashions are run, there’s a closing choice.  Does the reply make sense, or may there be parts lacking or misstated?  91% of the world being contaminated, raises a really severe query in regards to the validity of the mannequin with me. 

If the information media responds to analyses with single quantity
solutions, when these solutions aren’t correct, can there be any warranty of
creating a real understanding of the issue? 
I doubt it.  The consequence of
this kind “factual presentation” is that most people loses belief in any
statements which are revealed.  With that
can also be a lack of confidence in management. 
Scientific information should be offered precisely with the assumptions
accompanying the outcomes.   Integrity in each
step of the complete course of is required.

References:

  1. https://www.wsj.com/articles/curve-crushing-11587753699?cx_testId=3&cx_testVariant=cx_4&cx_artPos=1#cxrecs_s
  2. https://www.wsj.com/articles/the-media-vs-flatten-the-curve-11588113213?mod=hp_opin_pos_2
  3. https://kttc.com/2020/04/10/mayo-clinic-announces-temporary-furloughs-salary-reductions-for-some-employees/

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About Walt

I’ve been concerned in numerous elements of nanotechnology for the reason that late Nineteen Seventies. My curiosity in selling nano-safety started in 2006 and produced a white paper in 2007 explaining the 4 pillars of nano-safety. I’m a expertise futurist and is presently centered on nanoelectronics, single digit nanomaterials, and 3D printing on the nanoscale. My expertise contains three startups, two of which I based, 13 years at SEMATECH, the place I used to be a Senior Fellow of the technical employees once I left, and 12 years at Common Electrical with 9 of them on company employees. I’ve a Ph.D. from the College of Texas at Austin, an MBA from James Madison College, and a B.S. in Physics from the Illinois Institute of Know-how.

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