Cinnamon oil-based nanodevice successfully targets key pathogens, with potential makes use of in healthcare and meals security
A workforce of researchers from the Universitat Politècnica de València (UPV) and the CIBER de Bioingeniería, Biomaterials y Nanomedicine (CIBER-BBN) has created an progressive antimicrobial nanodevice using cinnamaldehyde, a vital oil element from cinnamon.
This “nano killer” has demonstrated appreciable effectiveness in combating pathogenic microorganisms similar to Escherichia coli, Staphylococcus aureus, and Candida albicans. The potential functions of this know-how embrace pathogen elimination in meals merchandise, wastewater remedy, and the administration of hospital-acquired infections.
Pathogen Impression and Software Strategies
The pathogens focused by this nanodevice could cause extreme well being points. Escherichia coli strains, for instance, are usually innocent however some can result in important belly ache, diarrhea, and vomiting. Staphylococcus aureus could trigger pores and skin and bloodstream infections, osteomyelitis, or pneumonia. Candida albicans, a fungus present in organic fluids, is understood for inflicting ailments like candidemia and invasive candidiasis.
UPV Crew. Credit score: UPV
The researchers say this utility of this “nanokiller” can be quite simple: “For instance, we may create a twig, make a formulation based mostly on water and different compounds, and apply it immediately. We may make a water-based formulation within the area and spray it immediately, like several pesticide in the present day. And in hospitals, it could possibly be utilized on bandages, and we may even attempt to make a capsule that could possibly be taken orally,” explains Andrea Bernardos, a researcher within the NanoSens group on the Inter-College Institute for Molecular Recognition Analysis and Technological Growth (IDM).
Enhanced Efficacy and Potential
The brand new nanodevice improves the efficacy of encapsulated cinnamaldehyde in comparison with the free compound: about 52-fold for Escherichia coli, about 60-fold for Staphylococcus aureus, and about 7-fold for Candida albicans.
“The rise within the antimicrobial exercise of the important oil element is feasible because of the lower in its volatility because of its encapsulation in a porous silica matrix and the rise in its native focus when launched because of the presence of the microorganisms,” mentioned Bernardos.
The machine stands out for its excessive antimicrobial exercise at very low doses. As well as, it enhances the antimicrobial properties of free cinnamaldehyde with a discount of the biocidal dose of round 98% for bacterial strains (Escherichia coli and Staphylococcus aureus) and 72% for the yeast pressure (Candida albicans) when the nanodevice is utilized.
“Furthermore, this kind of machine containing pure biocides (similar to important oil elements) whose launch is managed by the presence of pathogens is also utilized in fields similar to biomedicine, meals know-how, agriculture, and plenty of others,” concludes Ángela Morellá-Aucejo, additionally an IDM researcher on the Universitat Politècnica de València.
The outcomes of this examine have been revealed within the journal Biomaterials Advances.
Reference: “Outstanding enhancement of cinnamaldehyde antimicrobial exercise encapsulated in capped mesoporous nanoparticles: A brand new “nanokiller” method within the period of antimicrobial resistance” by Ángela Morellá-Aucejo, Serena Medaglia, María Ruiz-Rico, Ramón Martínez-Máñez, María Dolores Marcos and Andrea Bernardos, 26 March 2024, Biomaterials Advances.
DOI: 10.1016/j.bioadv.2024.213840